Process for the manufacture of iohexol
US7541494B2 · kind B2 · utility
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3References
17Claims
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Key dates
| Filing date | Mar 3, 2006 |
| Grant date | Jun 2, 2009 |
| Priority date | — |
| Expiry date | Mar 3, 2026 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C231/08
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A process for the production of iohexol comprises alkylating 5-Acetamido-N,N′-bis(2,3-dihydroxypropyl)-2,4,6-triiodoisophthalamide using 2(2-methoxy-ethoxy)-ethanol as solvent in the presence of a base, and optionally isolating crude iohexol from the reaction mixture. Preferably, the alkylating agent is 1-chloro-2,3 propanediol and the base is an alkali metal hydroxide such as sodium hydroxide or potassium hydroxide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.