Compositions for manipulating the lifespan and stress response of cells and organisms

US7544497B2 · kind B2 · utility

Assignees

• President and Fellows of Harvard College · US
• BIOMOL International L.P. · US

Inventors

• David A. Sinclair · Feldkirchen-Westerham, DE
• Konrad T. Howitz · Allentown, US
• Robert Elliot Zipkin · Wynnebrook Manor, US
• Kevin J. Bitterman · Boston, US
• Dudley W. Lamming · Somerville, US

Key dates

• Filing date: Jul 1, 2004
• Grant date: Jun 9, 2009
• Expiry date: Jul 8, 2024

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are methods and compositions for modulating the activity of sirtuin deacetylase protein family members; p53 activity; apoptosis; lifespan and sensitivity to stress of cells and organisms. Exemplary methods comprise contacting a cell with an activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin; or an inhibitory compound, such as a sphingolipid, e.g., sphingosine.