Constrained compounds as CGRP-receptor antagonists
US7544680B2 · kind B2 · utility
0Cited by
4References
9Claims
0Family size
Assignee
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Key dates
| Filing date | Apr 18, 2008 |
| Grant date | Jun 9, 2009 |
| Priority date | — |
| Expiry date | Apr 18, 2028 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P43/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.