Pyrazolopyridines and analogs thereof

US7544697B2 · kind B2 · utility

Assignee

• COLEY PHARMACEUTICAL GMBH · DE

Inventors

• David S. Hays · Woodbury, US
• Michael E. Danielson · Windom, US
• John F. Gerster · Woodbury, US
• Shri Niwas · Maple Grove, US
• Ryan B. Prince · Windom, US
• Tushar A. Kshirsagar · Woodbury, US
• Philip D. Heppner · Woodbury, US
• William H. Moser · Windom, US
• Joan T. Moseman · Lake Elmo, US
• Matthew R. Radmer · Robbinsdale, US
• Maureen A. Kavanagh · Stanchfield, US
• Sarah Strong · Louisville, US
• Jason D. Bonk · Hudson, US

Key dates

• Filing date: Apr 1, 2005
• Grant date: Jun 9, 2009
• Expiry date: Apr 28, 2026

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/14
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Pyrazolopyridin-4-amines, pyrazoloquinolin-4-amines, pyrazolonaphthyridin-4-amines, and 6,7,8,9-tetrahydropyrazoloquinolin-4-amines, pharmaceutical compositions containing the compounds, intermediates, methods of making, and methods of use of these compounds as immunomodulators, for inducing or inhibiting cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases, are disclosed.