Azabicyclo derivatives as muscarinic receptor antagonists

US7544708B2 · kind B2 · utility

Assignee

• RANBAXY LABORATORIES LIMITED · IN

Inventors

• Mohammad Salman · Barwala, IN
• Anita Mehta · Darien, US
• Pakala Kumara Savithru Sarma · Barwala, IN
• Shankar Jayram Shetty · Barwala, IN
• Sankaranarayanan Dharmarajan · Barwala, IN
• Naresh Kumar · Barwala, IN
• Arundutt Vishwanatham Silamkoti · Secunderabad, IN
• Anita Chugh · Delhi, IN

Key dates

• Filing date: Apr 11, 2003
• Grant date: Jun 9, 2009
• Expiry date: Aug 13, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention generally relates to muscarinic receptor antagonists which are useful, among other uses, for the treatment of various diseases of the respiratory, urinary and gastrointestinal systems mediated through muscarinic receptors. Specifically, the invention relates to derivatives of azabicyclo compounds, including, for example, 6-substituted azabicyclo[3.1.0] hexanes, and 2,4,6-trisubstituted derivatives. The invention also relates to pharmaceutical compositions containing the compounds and the methods of treating the diseases mediated through muscarinic receptors.