Tetrahydro-naphthalene derivatives as vanilloid receptor antagonists
US7544716B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 28, 2003 |
| Grant date | Jun 9, 2009 |
| Priority date | — |
| Expiry date | Nov 28, 2023 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07C2602/10
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
This invention relates to tetrahydro-naphthalene derivatives of formula (I)in which the variable groups are as defined in the specification and claims, and tautomeric and stereoisomeric forms and salts thereof which are useful as active ingredients of pharmaceutical preparations. The tetrahydro-naphthalene derivatives of the present invention have an excellent activity as VR1 antagonists and are useful for the prophylaxis and treatment of diseases associated with VR1 activity, in particular for the treatment of urinary incontinence, urge urinary incontinence, overactive bladder, chronic pain, neuropathic pain, postoperative pain, rheumatoid arthritic pain, neuralgia, neuropathies, algesia, nerve injury, ischaemia, neurodegeneration, stroke, inflammatory disorders, asthma and COPD. The compounds, pharmaceutical compositions containing them, and methods of treatment using them are disclosed and claimed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.