Peroxisome proliferator activated receptor agonists

US7544812B2 · kind B2 · utility

Assignee

• ELI LILLY AND COMPANY · US

Inventors

• Tracey Gibson · Indianapolis, US
• Richard Duane Johnston · Greenfield, US
• Nathan B. Mantlo · Westfield, US
• Richard Thompson · Frankfort, US
• Leonard Larry Winneroski, Jr. · Greenwood, US
• Yanping Xu · Noblesville, US
• Xiaodong Wang · Zhejiang, CN

Key dates

• Filing date: Nov 26, 2002
• Grant date: Jun 9, 2009
• Expiry date: Dec 22, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/12
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention is directed to compounds represented by the following structural Formula (I), (a) R1 is selected from the group consisting of hydrogen, substituted or unsubstituted group selected from C1-C8 alkyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, C3-C6 cycloalkylaryl-C0-2-alkyl, and —CH2—C(O)—R17-R18, wherein R17 is O or NH and R18 is optionally substituted benzyl; (b) R2 is selected from the group consisting of C1-C6 alkyl, C1-C6 alkenyl, aryl-C0-4-alkyl, heteroaryl-C0-4-alkyl, C1-C4 alkyl sulfonamide, C1-C4 alkyl amide, OR10 and C3-C6 cycloalkyl; (c) W is O or S; (d) X is an optionally substituted C1-C5 alkylene linker wherein one carbon atom of the linker may optionally be replaced with O, NH, S, and optionally two carbons together may form a double bond; (e) Y is selected from the group consisting of C, O, S, NH and a single bond; and (f) E is selected from the group consisting of C(R3)(R4)A, A, and a substituted or unsubstituted group selected from the group consisting of (CH2)n COOR19.