CD40-binding activating antibodies

US7547438B2 · kind B2 · utility

Assignee

• Pangenetics B.V. · NL

Inventors

• David Thomas · North York, CA
• Mark de Boer · Heemskerk, NL
• Pieter C. J. M. Res · Haarlem, NL
• Peter J. Simone · Hillegom, NL

Key dates

• Filing date: Dec 20, 2006
• Grant date: Jun 16, 2009
• Expiry date: May 11, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/31
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are agonist anti-CD40 molecules, including monoclonal antibodies, which can bind to and stimulate professional and non-professional human antigen-presenting cells (“APCs”), enhance the stimulatory effect of CD40L on CD40 positive cells and/or induce phenotypical maturation of monocyte derived dendritic cells. Several such monoclonal antibodies are provided, and cell lines producing them have been deposited at the American Type Culture Collection.