Bone replacement material comprising crystalline and X-ray amorphous phases

US7547448B2 · kind B2 · utility

Assignee

• BAM Bundesanstalt fuer Materialforschung und-pruefung · DE

Inventors

• Georg Berger · Panketal, DE
• Andrea Spitzer · Berlin, DE
• Christian Jäger · Berlin, DE
• Jutta Pauli · Berlin, DE
• Renate Gildenhaar · Berlin, DE

Key dates

• Filing date: Oct 20, 2003
• Grant date: Jun 16, 2009
• Expiry date: Jul 28, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61L2430/02
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention relates to an X-ray amorphous-crystalline material with high solubility which can be used as a bioactive bone replacement material and as a substrate material in biotechnology. The new material comprising crystalline and X-ray amorphous phases is characterized in that according to 31P-NMR measurements, it contains Q0-groups of orthophosphate and Q1-groups of diphosphate, the ortho-phosphates or Q0-groups making up 70 to 99.9% by weight relative to the total phosphorus content of the finished material and the diphosphates or Q1-groups making up 0.1 to 30% by weight relative to the total phosphorus content of the finished material, and that according to X-ray diffractometric measurements and relative to the total weight of the finished material, 30 to 99.9% by weight of a main crystal phase consisting of Ca2K1−xNa1+x(PO4)2, where x=0.1 to 0.9, is contained in the bone replacement material and 0.1 to 20% by weight of a substance selected from the group consisting of Na2CaP2O7, K2CaP2O7, Ca2P2O7 and mixtures thereof is contained as a secondary crystal phase, the X-ray amorphous phases contained besides the main crystal phase jointly making up 0.1 to 70% by weight …