Methods for reducing the formation of by-products in the production of recombinant polypeptides
US7547529B1 · kind B1 · utility
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6References
13Claims
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Key dates
| Filing date | May 10, 2001 |
| Grant date | Jun 16, 2009 |
| Priority date | — |
| Expiry date | May 10, 2021 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/58
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium in a method for producing a polypeptide containing a serine residue by culturing transformed cells, and a method for producing a polypeptide containing a serine residue by culturing transformed cells, characterized by reducing the formation of a byproduct polypeptide containing an O-acetylserine residue in place of a serine residue by adding at least one of histidine, methionine or glycine to the medium.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.