Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-coadesaturase (SCD)

US7547698B2 · kind B2 · utility

Assignee

• Xenon Pharmaceuticals Inc. · CA

Inventors

• Rajender Kamboj · Jamkhed, IN
• Jianmin Fu · Beijing, CN
• Vishnumurthy Kodumuru · Burnaby, CA
• Shifeng Liu · Port Coquitlam, CA
• Kashinath Sadalapure · Kalaburagi, IN
• Nagasree Chakka · Waltham, US
• Duanjie Hou · Burnaby, CA
• Shaoyi Sun · Coquitlam, CA

Key dates

• Filing date: Sep 20, 2005
• Grant date: Jun 16, 2009
• Expiry date: Sep 20, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise, for example, administering to a mammal in need thereof a compound of formula (I): where x, y, J, K, L, M, W, V, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.