Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
US7547704B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 6, 2004 |
| Grant date | Jun 16, 2009 |
| Priority date | — |
| Expiry date | Aug 13, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07H19/22
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
2′ and/or 3′ prodrugs of 1′, 2′, 3′ or 4′-branched nucleosides, and their pharmaceutically acceptable salts and derivatives are described. These prodrugs are useful in the prevention and treatment of Flaviviridae infections, including HCV infection, and other related conditions. Compounds and compositions of the prodrugs of the present invention are described. Methods and uses are also provided that include the administration of an effective amount of the prodrugs of the present invention, or their pharmaceutically acceptable salts or derivatives. These drugs may optionally be administered in combination or alteration with further anti-viral agents to prevent or treat Flaviviridae infections and other related conditions.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.