Methods for the production of insulin in plants
US7547821B2 · kind B2 · utility
19Cited by
10References
29Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jun 17, 2004 |
| Grant date | Jun 16, 2009 |
| Priority date | — |
| Expiry date | Jun 17, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N15/8257
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Commercial production of human insulin can be affected via transgenic expression in plant seeds. Thus, levels of insulin accumulation exceeding 0.1% of total cellular protein can be achieved recombinantly, through expression of the insulin with a single-chain antibody as a fusion partner. Production in seeds offers flexibility in storage and shipment of insulin as a raw material, and insulin retains its activity upon extraction from stored seed. Further, the amount of biomass subjected to extraction is limited, due to the relatively low water content of plant seeds.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.