Small volume in vitro analyte sensor

US7550069B2 · kind B2 · utility

Assignee

• ABBOTT DIABETES CARE INC. · US

Inventors

• Benjamin J. Feldman · Oakland, US
• Adam Heller · Austin, US
• Ephraim Heller · Piedmont, US
• Fei Mao · Fremont, US
• Joseph A. Vivolo · San Francisco, US
• Jeffery V. Funderburk · Fremont, US
• Fredric C. Colman · Berkeley, US
• Rajesh Krishnan · San Leandro, US

Key dates

• Filing date: Sep 12, 2003
• Grant date: Jun 23, 2009
• Expiry date: Mar 31, 2027

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y10T156/1052
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A sensor utilizing a non-leachable or diffusible redox mediator is described. The sensor includes a sample chamber to hold a sample in electrolytic contact with a working electrode, and in at least some instances, the sensor also contains a non-leachable or a diffusible second electron transfer agent. The sensor and/or the methods used produce a sensor signal in response to the analyte that can be distinguished from a background signal caused by the mediator. The invention can be used to determine the concentration of a biomolecule, such as glucose or lactate, in a biological fluid, such as blood or serum, using techniques such as coulometry, amperometry, and potentiometry. An enzyme capable of catalyzing the electrooxidation or electroreduction of the biomolecule is typically provided as a second electron transfer agent.