Docosahexaenoic acid producing strains of Yarrowia lipolytica
US7550286B2 · kind B2 · utility
39Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Nov 1, 2005 |
| Grant date | Jun 23, 2009 |
| Priority date | — |
| Expiry date | Dec 15, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA23V2002/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
An engineered strain of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 5.6% docosahexaenoic acid acid (DHA, an w-3 polyunsaturated fatty acid) in the total oil fraction is described. This strain comprises various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprises various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of DHA. Production host cells are claimed, as are methods for producing DHA within said host cells.
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