Spatially-defined macrocycles incorporating peptide bond surrogates
US7550431B2 · kind B2 · utility
11Cited by
4References
3Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 2, 2004 |
| Grant date | Jun 23, 2009 |
| Priority date | — |
| Expiry date | Oct 15, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K5/0802
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Novel spatially-defined macrocyclic compounds incorporating peptide bond surrogates are disclosed. Libraries of these macrocycles are then used to select one or more macrocycle species that exhibit a specific interaction with a particular biological target. In particular, compounds according to the invention are disclosed as agonists or antagonists of a mammalian motilin receptor and a mammalian ghrelin receptor.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.