Highly branched, unsubstituted or low-substituted starch products, dialysis solution and plasma expander containing the same, and the use thereof

US7550446B2 · kind B2 · utility

Assignee

• Fresenius Kabi Deutschland GmbH · DE

Inventor

• Klaus Henning · Usingen, DE

Key dates

• Filing date: Jul 30, 2003
• Grant date: Jun 23, 2009
• Expiry date: Jan 13, 2024

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08B31/12
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Known hydroxyethylated and -propylated starch types for use as colloid osmotic agent in peritoneal dialysis or as volume replacement composition (plasma expander) have the disadvantage that complete degradation by amylase is not possible owing to the more or less extensive substitution by hydroxyethyl or hydroxypropyl groups. As a consequence thereof, residual fragments remain in the body and are eliminated only very slowly or are stored in various organs/tissues, especially with relatively high and/or long-term dosage. These disadvantageous properties can be very substantially avoided according to the invention with a highly branched, unsubstituted or low-substituted starch product, i.e. with a starch which has a significantly higher degree of branching than amylopectin, and has the degree of α-I,6 branching of glycogen, or exceeds the latter and—if substituted—has a degree of substitution MS of only up to 0.3.