Amino substituted diaryl[a,d]cycloheptene analogs as muscarinic agonists and methods of treatment of neuropsychiatric disorders

US7550454B2 · kind B2 · utility

Assignee

• ACADIA Pharmaceuticals Inc. · US

Inventors

• Fredrik Ek · Lund, SE
• Roger Olsson · Bunkeflostrand, SE
• Jörgen Ohlsson · Lund, SE

Key dates

• Filing date: Dec 21, 2004
• Grant date: Jun 23, 2009
• Expiry date: Feb 17, 2026

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/28
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are analogs of clozapine and pharmaceutically acceptable salts, esters, amides, or prodrugs thereof; methods of synthesizing the analogs; and methods of using the analogs for treating neuropsychiatric disorders. In some embodiments, the analogs are amino substituted diaryl[a,d]cycloheptenes.