Imatinib production process

US7550591B2 · kind B2 · utility

Assignee

• Chemagis Ltd. · IL

Inventors

• Liu Xing · Shanghai, CN
• He Xungui · Shanghai, CN
• Yuan Wang · Hangzhou City, CN
• Michel Bekhazi · Rue du Bois des Loges, CA
• Sonia Krivonos · Beer Sheva, IL
• Edna Danon · Meitar, IL

Key dates

• Filing date: May 2, 2007
• Grant date: Jun 23, 2009
• Expiry date: May 2, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D295/155
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided is a process for producing imatinib and salts thereof, e.g., imatinib mesylate. The process includes reacting 4-(4-methyl-piperazin-1-ylmethyl)-benzoic acid with N-(5-amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidine-amine in the presence of a carboxylic acid coupling reagent, to produce imatinib, and optionally converting the imatinib into a salt.