Patent · US Active

Reversible electrochemical sensors for polyions

US7553403B2 · kind B2 · utility

1Cited by
5References
20Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJul 8, 2004
Grant dateJun 30, 2009
Priority date—
Expiry dateMay 13, 2027

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01N27/3335
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

The present invention is directed to a reversible electrochemical sensor for polyions. The sensor uses active extraction and ion stripping, which are controlled electrochemically. Spontaneous polyion extraction is suppressed by using membranes containing highly lipophilic electrolytes that possess no ion-exchange properties. Reversible extraction of polyions is induced by constant current pulse of fixed duration applied across the membrane. Subsequently, polyions are removed by applying a constant stripping potential. The sensors provide excellent stability and reversibility and allow for measurements of heparin concentration in whole blood samples via protamine titration.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.