Modulating neuronal outgrowth via the major histocompatibility complex class I (MHC I) molecule

US7553484B2 · kind B2 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Daniel L. Kaufman · Santa Monica, US
• Lorraine Hanssen · Los Angeles, US
• Dan Zekzer · Encinitas, US

Key dates

• Filing date: Jun 5, 2002
• Grant date: Jun 30, 2009
• Expiry date: Mar 7, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2501/01
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to methods and compositions for treating neural damage caused by injury or disease, by enhancing neural outgrowth and/or repair responses in the nervous system. Preferably, the methods and compositions utilize agents which interfere with the ability of the major histocompatibility complex (MHC) Class I molecule (MHC I) to inhibit neurite outgrowth. Such agents include antibodies directed to MHC I, MHC I fragments and/or analogs, and agents which interfere with MHC I interaction with its neuronal receptor and the receptor's signaling pathway.