Pantoprazole multiparticulate formulations

US7553498B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• Sripriya Venkata Ramana Rao · Mahwah, US
• Syed M. Shah · Delray Beach, US
• Hanumantharao Tatapudy · Suffern, US
• Richard Saunders · Dobbs Ferry, US
• Mahdi B. Fawzi · Morristown, US
• Arwinder Nagi · Thiells, US
• Shailesh Singh · Powder Springs, US
• Sumon A. Hasan · Rochester, US

Key dates

• Filing date: Mar 30, 2007
• Grant date: Jun 30, 2009
• Expiry date: Mar 30, 2027

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K9/1652
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A method of treating gastroesophageal reflux disease (GERD), ulcers of the stomach or duodenum, or Zollinger-Ellison Syndrome in a human, by administering pantoprazole sodium multiparticulates is described. The pantoprazole multiparticulates have a spheroid core of pantoprazole or an enantiomer thereof, or a salt thereof, a surfactant, and a disintegrant; a sub coat which is comprised of hydroxypropyl methylcellulose (hypromellose) and water, an enteric coat on the subcoat, and a final seal coat over the enteric coat, which is composed of hydroxypropyl methylcellulose (hypromellose) and water.