Three-dimensional skin model

US7553664B2 · kind B2 · utility

Assignee

• Max-Planck-Gesellschaft zur Föderung der Wissenschaften e.V. · US

Inventors

• Michaela Noll · Stuttgart, DE
• Thomas Graeve · Stuttgart, DE

Key dates

• Filing date: May 29, 2001
• Grant date: Jun 30, 2009
• Expiry date: Jul 4, 2022

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2533/54
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to methods for cultivating dermal fibroblasts, methods for preparing in vitro dermis equivalents, methods for preparing three-dimensional in vitro skin equivalents, an in vitro dermis equivalent, a three-dimensional in vitro skin equivalent, and methods for determining the effect of a chemical substance or of an agent on human skin cells using the in vitro dermis equivalent and/or the in vitro skin equivalent.