Glucocorticoid mimetics, methods of making them, pharmaceutical compositions, and uses thereof

US7553966B2 · kind B2 · utility

Assignee

• Boehringer Ingelheim Pharmaceuticals, Inc. · US

Inventors

• Rajashehar Betageri · Bethel, US
• Thomas A. Gilmore · Cambridge, US
• Christian Harcken · New Milford, US
• Daniel Kuzmich · Clovis, US
• Hossein Razavi · Danbury, US
• Doris Riether · Biberach an der Riß, DE
• David Thomson · Ridgefield, US
• Ji Wang · Amherst, US

Key dates

• Filing date: Sep 17, 2004
• Grant date: Jun 30, 2009
• Expiry date: Oct 8, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of Formula (IA) and Formula (IB)wherein R1, R2, R3, R4, R5, and R6 are as defined herein for Formula (IA) or Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.