Method for non-invasively determining the relative levels of two biological substances
US7555337B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jun 17, 2002 |
| Grant date | Jun 30, 2009 |
| Priority date | — |
| Expiry date | Dec 11, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61B5/1486
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The method for non-invasively determining the relative levels of two substances present in a biological system includes the steps of extracting by reverse iontophoresis charged and uncharged substances from said biological system, and collecting said substances, analysing the collected amount of a first extracted substance and a second extracted substance and determining the extraction ratio of the first substance to the second substance to determine their relative levels in the biological system. When the first and second substances are both analytes susceptible to changes in their concentration in the biological system, this method provides information about the relative concentrations of the two substances in the biological system. When the first substance is an analyte susceptible to changes in its concentration in the biological system and the second substance has a substantially constant concentration in the biological system, the second subtance acts as an internal standard and the extraction ratio becomes a direct measurement of the physiological level of the first substance in the biological system. A iontophoretic sampling device for monitoring the relative levels of two …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.