Methods and compositions for treating intervertebral disc degeneration
US7556649B2 · kind B2 · utility
13Cited by
140References
25Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Mar 29, 2004 |
| Grant date | Jul 7, 2009 |
| Priority date | — |
| Expiry date | Apr 10, 2025 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2430/38
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A fluid matrix comprising cross-linked remodelable collagen from a donor vertebrate animal is useful for regenerating hydrodynamic function in damaged intervertebral discs in vivo. The matrix may be injectable and may comprise cells and a plurality of purified cell growth factors. The matrix promotes cell growth and elaboration of proteoglycans to facilitate regeneration of native tissues. The collagen in the matrix may be cross-linked using photooxidative catalysis and visible light, and purified cell growth factors are preferably at least partly bone-derived.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.