Anthracycline antibiotics and methods of treating cancer using the same
US7557090B2 · kind B2 · utility
2Cited by
4References
34Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 1, 2006 |
| Grant date | Jul 7, 2009 |
| Priority date | — |
| Expiry date | Apr 14, 2027 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/704
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention discloses new and novel substituted anthracyclines with modified alkyl-aromatic ring substitutions on the C-3′ of the sugar moiety or modified or unmodified alkyl-aromatic ring substitutions at the C-4′ of the sugar moiety. It also discloses novel methods for the preparation of sugar substrates and methods for the preparation of anthracycline antibiotics. These anthracycline analogs show high cytotoxicity in vitro against several tumor cell lines.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.