Pyrazolidine-1,2-dicarboxyldiphenylamide derivatives as coagulation factor Xa inhibitors for the treatment of thromboses

US7557102B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Werner Mederski · Zwingenberg, DE
• Christos Tsaklakidis · Weinheim, DE
• Dieter Dorsch · Ober-Ramstadt, DE
• Bertram Cezanne · Mörfelden, DE
• Johannes Gleitz · Darmstadt, DE

Key dates

• Filing date: Mar 9, 2004
• Grant date: Jul 7, 2009
• Expiry date: Sep 29, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D453/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Novel compounds of the formula (I), in which R, R1, R2 and R3 have the meanings indicated in Patent Claim 1, are inhibitors of coagulation factor Xa and can be employed for the prophylaxis and/or therapy of thromboembolic diseases and for the treatment of tumors.