Inhibitors of cytosolic phospholipase A2

US7557135B2 · kind B2 · utility

Assignee

• Wyeth, LLC · US

Inventors

• John C. McKew · Ames, US
• Katherine Lin Lee · Newton, US
• Lihren Chen · Cambridge, US
• Richard Vargas · Bedford, US
• James D. Clark · Acton, US
• Cara Williams · Methuen, US
• Valerie Clerin · Watertown, US
• Suzana Marusic · Reading, US
• Kevin Pong · Lawrence, US

Key dates

• Filing date: May 26, 2006
• Grant date: Jul 7, 2009
• Expiry date: Jan 12, 2027

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/18
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides chemical inhibitors of the activity of various phospholipase enzymes, particularly cytosolic phospholipase A2 enzymes (cPLA2), more particularly including inhibitors of cytosolic phospholipase A2 alpha enzymes (cPLA2α). In some embodiments, the inhibitors have the Formula I:wherein the constituent variables are as defined herein.