Amine derivative with potassium channel regulatory function, its preparation and use

US7560473B2 · kind B2 · utility

Assignee

• INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY, ACADEMY OF MILITARY MEDICAL SCIENCES · CN

Inventors

• Hai Wang · San Diego, US
• Liuhong Yun · Beijing, CN
• Huasong Feng · Beijing, CN
• Fulin Li · Beijing, CN
• Xingchun Tang · Beijing, CN
• Huamei He · Beijing, CN
• Rifang Yang · Beijing, CN
• Wenyu Cui · Beijing, CN
• Qixiu Gao · Beijing, CN
• Gang HU · Beijing, CN
• Rusheng Zhao · Beijing, CN
• Wei Liu · Hangzhou City, CN
• Chaoliang Long · Beijing, CN
• Lin Wang · Qingdao, CN
• Xinqiang Lu · Beijing, CN
• Lijun Liu · 安丰镇, CN
• Yuan-Yong Yan · 红钢城街道, CN

Key dates

• Filing date: Jan 21, 2002
• Grant date: Jul 14, 2009
• Expiry date: Jun 5, 2023

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C211/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides amine derivatives represented by formula I, its isomers, racemes or optical isomers, pharmaceutical salts thereof, its amides or esters, pharmaceutical compositions containing said compounds and the preparation methods thereof. The invention also relates to the use of the above mentioned compounds in the preparation of drugs for the prophylaxis or treatment of cardiovascular diseases, diabetes, bronchial and urinary smooth muscle spasm as well as ischemic and anoxic nerve injury. The above compounds can be used to treat hypertension, angina diaphragmatic, myocardial infarction, congestive heart failure, arrhythmia, diabetes, spasmodic bronchial diseases, spasmodic bladder or ureter diseases, and depression.