Method for the production of OH protected[4-(2.6-diamino-9H-purine-9-yl)-1.3-dioxolane-2-yl]methanol derivatives

US7560550B2 · kind B2 · utility

Assignee

• RFS Pharma LLC · US

Inventors

• Wolfgang Döring · Mehring, DE
• Hermann Petersen · Burghausen, DE

Key dates

• Filing date: Jul 22, 2004
• Grant date: Jul 14, 2009
• Expiry date: Aug 27, 2025

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D473/16
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Glycosylation of 2,6-diaminopurines or silyl derivatives thereof with a compound of the structureis facilitated by the presence of an optionally silylated 1,3-dicarbonyl compound during glycosylation. Byproducts are minimized, while stereoselectivity may be altered by choice of Lewis acid and other reaction condictions.