Process for screening chemical compounds for modulating the interaction of an EVH1 domain and a process for detecting said interaction

US7563582B2 · kind B2 · utility

Assignee

• Sanofi-Aventis Deutschland GMBH · DE

Inventors

• Birgit Jordan · Hattersheim, DE
• Peter Druckes · Glückstadt, DE
• Thomas Jarchau · Coburg, DE
• Ulrich Walter · Langenfeld, DE

Key dates

• Filing date: Nov 21, 2001
• Grant date: Jul 21, 2009
• Expiry date: Apr 15, 2023

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2500/00
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The invention relates to processes for identifying chemical compounds which are capable of modulating the interaction between VASP and zyxin. VASP or a VASP derivative and zyxin or a zyxin derivative which interact with one another are brought into contact with a chemical compound to be examined. The effect on the interaction can be determined using antibodies against VASP or a VASP derivative and/or zyxin or a zyxin derivative, or with the aid of fluorescent labels on VASP or a VASP derivative and zyxin or a zyxin derivative.