FGF variants and methods for use thereof
US7563769B2 · kind B2 · utility
48Cited by
31References
35Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Nov 5, 2004 |
| Grant date | Jul 21, 2009 |
| Priority date | — |
| Expiry date | Oct 29, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1346
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides fibroblast growth factor variants demonstrating enhanced receptor subtype specificity and/or affinity. Preferred embodiments include both variants having enhanced activity that act as improved agonists and variants having reduced activity that act as antagonists. Methods of utilizing preferred FGF variants in preparation of medicaments for the treatment of skeletal disorders including skeletal dysplasia, osteoporosis and enhancing bone fracture healing and cartilage healing processes are provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.