Method for preparing paclitaxel
US7563914B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Feb 21, 2006 |
| Grant date | Jul 21, 2009 |
| Priority date | — |
| Expiry date | Feb 21, 2026 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P35/00
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention concerns a method for preparing paclitaxel characterized in that it consists in starting with 10-deacetyl-baccatine in accordance with a “one-pot” reaction including the following three steps: a) protecting the hydroxy radical in position 7 of 10-deacetylbaccatine with a silylated radical, then b) acetylating the hydroxy radical in position 10, c) optionally crystallizing the resulting baccatine III derivative, followed by condensation of (4S,5R)-3-N-benzoyl-2RS-methoxy-4-phenyl-1,3-oxazolidine-5-carboxylic acid, by esterifying in position 13 the acetylated 10-baccatine III derivative previously obtained, then opening the oxazolidine of the cyclic side chain and simultaneously releasing the hydroxy radical in position 7.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.