Method for the determination of a light transport parameter in a biological matrix
US7565249B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 23, 2002 |
| Grant date | Jul 21, 2009 |
| Priority date | — |
| Expiry date | Oct 28, 2023 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY10T436/144444
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method is proposed for the selective determination of a light transport parameter which is characteristic for the light scattering in a biological matrix (5), in particular for the purpose of the non-invasive determination of the glucose concentration in the biological matrix. The method comprises providing a plurality of detection measurements, in which light is irradiated as primary light into the biological matrix and measuring an intensity value of secondary light emerging at a plurality detection sites, located in different measuring distances from the irradiation site. In an evaluation step, the light transport parameter is derived, by means of an evaluation algorithm, from the measured intensity values. For the selective determination of the scattering coefficient, the evaluation algorithm includes a step in which a time derivative value ΔtI(r) describing the change of the measurement intensity value versus time is calculated from intensity measurement values obtained at a minimum of two different points of time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.