Method and composition for inhibition of angiogenesis using antagonists based on MMP-9 and β1 integrins
US7566449B2 · kind B2 · utility
5Cited by
9References
24Claims
0Family size
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Key dates
| Filing date | Mar 25, 2005 |
| Grant date | Jul 28, 2009 |
| Priority date | — |
| Expiry date | Aug 24, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/34
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Antagonists for modifying protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are described. Such antagonists inhibit angiogenesis, tumor growth and disease states. Example antagonists are polypeptide and non-polypeptide molecules, including the novel antibody Mab FM155 and the novel synthetic peptide FRIP-1. Methods for inhibiting angiogenesis and disease states by administering such antagonists are disclosed. Methods for identifying antagonists that modify protein-protein interactions involving certain amino acid sequences within MMP-9 and/or β1 integrins are also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.