MRI method for measuring tumor hemodynamic parameters in the presence of contrast agent extravasation
US7567832B2 · kind B2 · utility
10Cited by
3References
10Claims
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Key dates
| Filing date | Aug 12, 2005 |
| Grant date | Jul 28, 2009 |
| Priority date | — |
| Expiry date | Mar 17, 2027 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01R33/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
One or two sets of time course NMR data are acquired using an EPI pulse sequence in which either or both gradient recalled echo NMR signals and spin-echo NMR signals are acquired after bolus injection of a contrast agent. T2* relaxation rates for GE and T2 relaxation rates for SE are calculated from the acquired NMR signals and are corrected for extravasation of contrast agent into surrounding tissues. The gradient-echo signals and spin-echo NMR signals are employed along with the T2* and T2 relaxation rates to calculate hemodynamic parameter maps which are used as a measure of tumor angiogenesis.
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