Immunogenic lipopeptides comprising T-helper and B-cell epitopes
US7569225B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 12, 2003 |
| Grant date | Aug 4, 2009 |
| Priority date | — |
| Expiry date | Apr 20, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/6068
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides synthetic immunogenic lipopeptide molecules comprising co-linear T-helper and B cell epitopes, and methods for their production and use in the generation of primary and secondary immune responses, and for the vaccination of animal subjects against particular antigens. More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. Preferably the internal lysine or lysine analog is positioned between the T-helper epitope and the B cell epitope or within the T-helper epitope.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.