Nucleic acid directed immobilization arrays and methods of assembly
US7569341B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 7, 1997 |
| Grant date | Aug 4, 2009 |
| Priority date | — |
| Expiry date | Nov 7, 2017 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/682
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention relates to supramolecular bioconjugates and to methods for assembling and utilizing supramolecular bioconjugates. Supramolecular bioconjugates comprise a plurality of first nucleic acids and a plurality of mediators wherein each mediator comprises a second nucleic acid complementary to a sequence within said plurality of first nucleic acids. To assemble a supramolecular bioconjugate, one or more sets of bioreactive agents are coupled to the plurality of mediators, forming a plurality of bioreactive complexes The plurality of bioreactive complexes are hybridized to the plurality of first nucleic acids to form the supramolecular bioconjugate. Bioconjugates can be used to detect and isolate targets, to screen samples for targets such as antigens, to treat patients with multiple agents or to diagnose disorders in the form of a kit.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.