Detection of human papilloma virus in papanicolaou (Pap) smears
US7569344B2 · kind B2 · utility
1Cited by
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10Claims
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Key dates
| Filing date | Aug 22, 2003 |
| Grant date | Aug 4, 2009 |
| Priority date | — |
| Expiry date | Apr 17, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/708
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Methods and reagents for detecting high-risk human papilloma virus (HPV) DNA types in cells on a Pap smear that indicates the patient is at higher risk for cancer are described. The method uses full-length DNA probes to HPV types 16, 18, 31, 33, 35, and 51 in a particular proportion to hybridize to and detect the viral DNA in situ. The method differentiates high-risk from low-risk HPV DNA in cells that indicates the patient's risk for cancer. The in situ hybridization is detected by brightfield microscopy.
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