Patent · US Expired

Method for identifying modulators of the dioxin/aryl hydrocarbon receptor (AHR)

US7569352B2 · kind B2 · utility

5Cited by

2References

6Claims

0Family size

Assignee

Index Pharmaceuticals AB · SE

Inventors

Petra Von Stein · Spånga, SE
Patrik Andersson · Västerås, SE
Nikolai Kouznetsov · Järfälla, SE
Lorenz Poellinger · Stockholm, SE

Key dates

Filing date	May 13, 2004
Grant date	Aug 4, 2009
Priority date	—
Expiry date	May 27, 2024

Classification

Technology area (CPC G)Physics
CPC primaryG01N2500/04
WIPO fieldMeasurement
WIPO sectorInstruments

Abstract

Agents useful for modulating the dioxin/aryl hydrocarbon receptor (AhR) can now be identified by determining the binding to said receptor and whether said agent suppresses or inhibits the expression of a gene substantially consisting of a sequence according to one of SEQ. ID. NO. 1 and SEQ. ID. NO. 2; a nucleotide sequence functionally homologous, or substantially homologous, or at least 90% identical to one of SEQ. ID. NO. 1 and SEQ. ID. NO. 2; and a nucleotide sequence complementary to the nucleotide sequence of SEQ. ID. NO. 1 or SEQ. ID. NO. 2. Such agents find utility in pharmaceutical compositions and methods for the prevention, alleviation or treatment of diseases involving gastrointestinal hyperplasia, such as gastrointestinal cancer or gastric cancer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.