Multiplex spatial profiling of gene expression
US7569392B2 · kind B2 · utility
23Cited by
1References
40Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Jan 7, 2005 |
| Grant date | Aug 4, 2009 |
| Priority date | — |
| Expiry date | Jun 6, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2458/15
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention provides mass tag complexes that permit simultaneously obtaining information of a plurality of biological molecules. The biological molecules may be RNA or protein, and the information includes both level of expression as well as spatial disposition within a cell or tissue. The mass tag comprise a core structure, a target binding structure (e.g., nucleic acid or peptide binding structure), a cleavable linker and a mass tag that exhibits a unique mass spectroscopy signal.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.