Patent · US Active

Compositions of estrogen-cyclodextrin complexes

US7569557B2 · kind B2 · utility

1Cited by

14References

16Claims

0Family size

Assignee

Bayer Schering Pharma AG · DE

Inventors

Thomas Backensfeld · Berlin, DE
Wolfgang Heil · Berlin, DE
Ralph Lipp · Berlin, DE

Key dates

Filing date	Dec 4, 2006
Grant date	Aug 4, 2009
Priority date	—
Expiry date	Oct 2, 2027

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC08B37/0015
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Pharmaceutical compositions comprising low doses of sensitive complexes between an estrogen and a cyclodextrin are provided with improved stability. In specific embodiments the composition comprises a complex between ethinyl estradiol and β-cyclodextrin in a granulate preparation and in yet another embodiment the composition comprises a limited amount of polyvinylpyrrolidone since this excipient was found to degrade ethinyl estradiol. Furthermore, a method for improving the stability of an estrogen in a composition and for manufacturing such a stable composition is provided. Essentially, the granulate preparation are manufactured under careful control of the relative humidity.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.