Purine derivatives, the preparation thereof and their use as pharmaceutical compositions

US7569574B2 · kind B2 · utility

Assignee

• BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG · DE

Inventors

• Roland Maier · Biberach an der Riß, DE
• Frank Himmelsbach · Mittelbiberach, DE
• Matthias Eckhardt · Hannover, DE
• Elke Langkopf · Biberach an der Riß, DE
• Michael Mark · Biberach an der Riß, DE
• Ralf Lotz · Schemmerhofen, DE

Key dates

• Filing date: Aug 4, 2003
• Grant date: Aug 4, 2009
• Expiry date: Sep 23, 2023

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P3/10
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention relates to new purine derivatives of general formulawherein R1 to R4 are defined as in the claims, the tautomers, the stereoisomers, the mixtures, the prodrugs thereof and the salts thereof, particularly the physiologically acceptable salts thereof with inorganic or organic acids or bases which have valuable pharmacological properties, particularly an inhibiting effect on the activity of the enzyme dipeptidylpeptidase-IV (DPP-IV), the preparation thereof, the use thereof for the prevention or treatment of diseases or conditions associated with an increased DPP-IV activity or capable of being prevented or alleviated by reducing the DPP-IV activity, particularly type I or type II diabetes mellitus, the pharmaceutical compositions containing a compound of general formula (I) or a physiologically acceptable salt thereof as well as processes for the preparation thereof.