Mutant having uracil phosphoribosyl transferase activity
US7572438B2 · kind B2 · utility
7Cited by
2References
7Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Oct 31, 2005 |
| Grant date | Aug 11, 2009 |
| Priority date | — |
| Expiry date | Oct 31, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2799/022
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.