Enzyme disruption of bacterial biofilms
US7572439B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Mar 26, 2003 |
| Grant date | Aug 11, 2009 |
| Priority date | — |
| Expiry date | Feb 8, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61L2300/45
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods for treating patients in which damaged tissue or an indwelling prosthetic device or catheter has a bacterial biofilm growing thereon, to at least partially disrupt said biofilm, by administering at least one antibacterial enzyme that is lethal or damaging to the biofilm-forming bacteria in an amount that is effective to at least partially disrupt the biofilm upon contact therewith. Methods for prophylactically treating a patient, and methods for disinfecting or sterilizing a surface ex-vivo to remove a biofilm or prevent biofilm growth are also disclosed, as well as implantable articles susceptible to biofilm growth to which a prophylactic coating of an antibacterial enzyme has been applied.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.