Construct comprising recognition domain of antibody against von Willebrand factor-specific cleaving enzyme
US7572591B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Mar 17, 2004 |
| Grant date | Aug 11, 2009 |
| Priority date | — |
| Expiry date | May 18, 2024 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K2039/505
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides an epitope recognized by an antibody (hereinafter, also referred to as an anti-ADAMTS-13 antibody) against a cleaving protease (hereinafter, also referred to as ADAMTS-13) specific to von Willebrand factor (hereinafter, also referred to as vWF), and a polypeptide comprising the epitope region. The present invention also provides a polypeptide located in a region from position 449 to position 687 in an amino acid sequence composing the ADAMTS-13, which is recognized by the anti-ADAMTS-13 antibody, or a peptide fragment derived from the polypeptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.