Metalloprotease activation of myostatin, and methods of modulating myostatin activity
US7572599B2 · kind B2 · utility
7Cited by
1References
9Claims
0Family size
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Key dates
| Filing date | Sep 16, 2003 |
| Grant date | Aug 11, 2009 |
| Priority date | — |
| Expiry date | Jun 10, 2024 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2319/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
It has been determined that metalloprotease cleavage of a myostatin pro peptide results in activation of a latent inactive myostatin to an active form. Accordingly, methods of identifying agents that modulate metalloprotease mediated activation of myostatin are provided, as are agents identified using such methods. Also provided are methods of modulating muscle growth in an organism by increasing or decreasing metalloprotease mediated cleavage of a myostatin pro peptide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.