Enzymatic activities in chemokine-mediated inflammation
US7572600B2 · kind B2 · utility
1Cited by
22References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 4, 2005 |
| Grant date | Aug 11, 2009 |
| Priority date | — |
| Expiry date | Dec 3, 2026 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/52
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Truncated chemokines lacking an N-terminal region that activate CCR1 and/or FPRL1 and compositions containing the truncated chemokines are provided. Methods of identifying agents that modulate CCR1 and/or FPRL1 activity either by modulating the production of the truncated chemokines or the ability of the truncated chemokines to activate CCR1 and/or FPRL1 are also disclosed. Methods using the truncated chemokines to inhibit or activate CCR1 and/or FPRL1 mediated biological activities are also disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.