Nucleic acid encoding endolysin fusion protein
US7572602B1 · kind B1 · utility
16Cited by
0References
10Claims
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Inventor
Key dates
| Filing date | Dec 5, 2005 |
| Grant date | Aug 11, 2009 |
| Priority date | — |
| Expiry date | Dec 5, 2025 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2795/00011
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention concerns a recombinant nucleic acid molecule encoding an antimicrobial fusion peptidoglycan endopeptidase. The recombinant nucleic acid molecule according to the invention is formed from a nucleic acid encoding a bacterial endopeptidase (lysostaphin) from Staphylococcus simulans and a nucleic acid encoding a second endopeptidase (endolysin) module from Group B streptococcal bacteriophage B30. The encoded fusion endopeptidase has antimicrobial activity and kills both Staphylococcus bacteria and Streptococcus bacteria.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.